Skip to main content

  • Login
Asma grave: servizi per i professionisti della salute - The Next Breath | go to homepage
INFIAMMAZIONE DI TIPO 2
COMORBIDITÀ
INFORMAZIONI UTILI
SERVIZI PER IL MEDICO
  • SERVIZI PER IL MEDICO
  • Registrazione
  • Modifica Profilo Utente
  • Login
Cerca
Asma grave: servizi per i professionisti della salute - The Next Breath | go to homepage
Cerca
Asma grave: servizi per i professionisti della salute - The Next Breath | go to homepage
INFIAMMAZIONE DI TIPO 2
COMORBIDITÀ
INFORMAZIONI UTILI
SERVIZI PER IL MEDICO
  • SERVIZI PER IL MEDICO
  • Registrazione
  • Modifica Profilo Utente
  • Login
  • Login
  • Cerca
    • Asma grave: servizi per i professionisti della salute - The Next Breath
    • Login

    Login

    {* #signInForm *} {* signInEmailAddress *} {* currentPassword *}

    Hai dimenticato la password? Clicca qui

    Registrati

    {* /signInForm *}

    Bentornata anonymous

    Logout

    Verifica e-mail richiesta

    Per completare la registrazione, controlla la tua casella di posta e clicca sul link per confermare l’indirizzo mail. Per maggiori informazioni puoi contattarci qui

    Ha dimenticato la password

    Se hai dimenticato la password, inserisci il tuo indirizzo email. Riceverai un link via e-mail per creare una nuova password.

    {* #forgotPasswordForm *} {* signInEmailAddress *}
    {* /forgotPasswordForm *}

    Crea nuova password

    Abbiamo inviato un'e-mail con le istruzioni per creare una nuova password. La tua password esistente non è stata modificata.

    Ok

    Crea nuova password

    Questo indirizzo email è stato registrato con un account social. Abbiamo inviato un'e-mail con le istruzioni per creare una nuova password, che può essere utilizzata in aggiunta ai tuoi provider social collegati.
    Ok

    Cambia la password

    {* #changePasswordFormNoAuth *} {* newPassword *} {* newPasswordConfirm *}
    {* /changePasswordFormNoAuth *}

    Password cambiata

    La tua password è stata aggiornata con successo.

    Accedi

    Crea nuova password

    Non abbiamo riconosciuto il codice di reimpostazione della password. Inserisci la tua email qui sotto e ti invieremo un'altra email.

    {* #resetPasswordForm *} {* signInEmailAddress *}
    {* /resetPasswordForm *}

    Password cambiata

    La tua password è stata aggiornata con successo.

    Accedi

    Impossibile fare il log in

    Non siamo in grado di accedere in questo momento. Riprova più tardi o contatta l'assistenza clienti.

    HCP Verifica richiesta

    Attenzione! Certificazione dei dati in corso, a conclusione riceverai un’email di conferma e potrai accedere all’area a te dedicata. Per maggiori informazioni puoi contattarci qui

    Mappa del sito

    Condizioni di utilizzo

    Cookie Policy

    Privacy Policy

    Bibliografia

    Contatti

    Sanofi S.r.l. - Direzione e Coordinamento Sanofi (Francia)
    Sede legale: Viale Luigi Bodio, 37/b - 20158 Milano Cap. Soc. € 202.279.195,04 I.v.
    Reg. Imprese Milano /C.F./P. IVA 00832400154 - sanofi@pec.it
    ©2021 Sanofi S.r.l. - Direzione e Coordinamento Sanofi (Francia)
    Sito sviluppato per il territorio italiano

    Bibliografia

    INFIAMMAZIONE DI TIPO 2

    Fisiopatologia e prevalenza

    1. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.
    2. Robinson D et al. Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161-175.
    3. Global Initiative for Asthma. Diagnosis and Management of Difficult-to-treat and Severe Asthma in adolescent and adult patients. v2.0 April 2019, Pocket Guide.
    4. Peters MC et al. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb;133(2):388-94.
    5. Gauthier M et al. Am J Respir Crit Care Med. 2015 Sep 15;192(6):660-8.
    6. Chung KF. Targeting the interleukin pathway in the treatment of asthma. Lancet. 2015 Sep 12;386(9998):1086-96.
    7. Fahy JV. Nat Rev Immunol. 2015 Jan;15(1):57-65.

    Meccanismi molecolari

    1. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.
    2. Robinson D et al. Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161-175.
    3. Chung KF. Targeting the interleukin pathway in the treatment of asthma. Lancet. 2015 Sep 12;386(9998):1086-96.
    4. Junttila IS. Tuning the Cytokine Responses: An Update on interleukin (iL)-4 and iL-13 Receptor Complexes. Front Immunol. 2018 Jun 7;9:888.
    5. Israel E & Reddel HK. Severe and Difficult-to-Treat Asthma in Adults. N Engl J Med. 2017 Sep 7;377(10):965-976.
    6. Shinkai A et. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 1999 Aug 1;163(3):1602-10.
    7. Steinke JW & Borish L. Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists Respir Res. 2001;2(2):66-70.

    Marker infiammazione di tipo 2

    1. Parulekar AD et al. Role of T2 inflammation biomarkers in severe asthma. Curr Opin Pulm Med. 2016 Jan;22(1):59-68.
    2. Katial RK et al. Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2S):S1-S14.
    3. Prado CM et al. Nitric Oxide in Asthma Physiopathology. ISRN Allergy. 2011 Apr 19;2011:832560.
    4. Guzik TJ et al. Nitric Oxide and Superoxide in Inflammation and Immune Regulation. J Physiol Pharmacol. 2003 Dec;54(4):469-87.
    5. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.
    6. Rosenberg HF et al. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol. 2007 Jun;119(6):1303-10.
    7. de Vries IJ et al. Adhesion molecule expression on skin endothelia in atopic dermatitis: Effects of TNF-a and IL-4 J Allergy Clin Immunol. 1998 Sep;102(3):461-8.
    8. Shinkai A et. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 1999 Aug 1;163(3):1602-10.
    9. Global Initiative for Asthma. Diagnosis and Management of Difficult-to-treat and Severe Asthma in adolescent and adult patients. v2.0 April 2019, Pocket Guide.

    Cascata infiammatoria

    1. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.
    2. McGregor MC et al. Role of Biologics in Asthma. Am J Respir Crit Care Med. 2019 Feb 15;199(4):433-445.

    COMORBIDITÀ

    Comorbidità di tipo 2

    1. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease Nat Rev Drug Discov 2016;15(1):35-50.
    2. Carr S and Watson W. Eosinophilic esophagitis. Allergy Asthma Clin Immunol. 2011;7(Suppl 1):S8.

    Rinosinusite cronica con poliposi nasale

    1. Kato A. Immunopathology of chronic rhinosinusitis. Allergol Int. 2015 Apr;64(2):121-30.
    2. Schleimer RP. Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. Annu Rev Pathol. 2017;12:331-357.
    3. Ceylan E et al. Nasal polyps and the severity of asthma. Respirology. 2007 Mar;12(2):272-6.
    4. Chaaban MR et al. Epidemiology and differential diagnosis of nasal polyps. Am J Rhinol Allergy 2013;27(6):473-478.
    5. Hulse KE et al. Pathogenesis of nasal polyposis. Clin Exp Allergy. 2015 Feb;45(2):328-46.
    6. Chung KF. Targeting the interleukin pathway in the treatment of asthma. Lancet. 2015 Sep 12;386(9998):1086-96.
    7. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease Nat Rev Drug Discov 2016;15(1):35-50.
    8. Dietz de Loos DA, et al. Symptoms in chronic rhinosinusitis with and without nasal polyps. Laryngoscope. 2013 Jan;123(1):57-63.
    9. Yamada T et al. Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis. Front Immunol. 2019 Feb 4;10:74.
    10. Robinson D et al. Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017 Feb;47(2):161-175.
    11. Corren J et al. Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526.
    12. McGregor MC et al. Role of Biologics in Asthma. Am J Respir Crit Care Med. 2019 Feb 15;199(4):433-445.
    13. Takabayashi T et al. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. Am J Respir Crit Care Med. 2013 Jan 1;187(1):49-57.
    14. Stevens WW et al. Chronic rhinosinusitis with nasal polyps. J Allergy Clin lmmunol Pract 2016;4(4):565-572.
    15. Akdis CA et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin lmmunol 2013;131(6):1479-1490.
    16. Khan A et al. The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. Rhinology. 2019;57(1):32-42.
    17. Langdon C, Mullol J. Nasal polyps in patients with asthma: prevalence, impact, and management challenges. J Asthma Allergy 2016;9:45-53.
    18. Bachert C et al. ICON: chronic rhinosinusitis. World Allergy Organ J 2014;7(1):25.
    19. Head K et al. Short-course oral steroids alone for chronic rhinosinusitis. Cochrane Database Syst Rev 2016;4:CD011991.
    20. Fokkens WJ et al. European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 2012;50(23):1-298.
    21. Vaidyanathan S et al. Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids. Ann Intern Med 2011;154(5):293-302.
    22. Van Zele T et al. Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 2014;28(3):192-198.
    23. Stevens WW et al. Clinical characteristics of patients with chronic rhinosinusitis with nasal polyps, asthma, and aspirin-exacerbated respiratory disease. J Allergy Clin lmmunol Pract 2017;5(4):1061-1070. 8.
    24. De Greve G et al. Endotype‑driven treatment in chronic upper airway diseases. Clin Transl Allergy. 2017 Jul 12;7:22.
    25. xAIFA - Farmaci biologici. Da: https://www.aifa.gov.it/farmaci-biologici [Ultimo accesso: settembre 2020].x
    26. ISS - Farmaco chimico. Da: https://www.iss.it/farmaco-chimico. [Ultimo accesso: settembre 2020].
    27. EMA - Medicinali biosimilari nell'UE - Guida informativa per gli operatori sanitari. Da: https://www.ema.europa.eu/en/documents/leaflet/biosimilars-eu-information-guide-healthcare-professionals_it.pdf [Ultimo accesso: settembre 2020].
    28. Foltz IN et al. Evolution and Emergence of Therapeutic Monoclonal Antibodies. Circulation. 2013 Jun 4;127(22):2222-30.
    29. Fokkens WJ et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020 Feb 20;58(Suppl S29):1-464.

    Dermatite atopica

    1. Gelmetti C et al. Dermatite atopica 2016-2017. Sidemast.
    2. Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease Nat Rev Drug Discov 2016;15(1):35-50.
    3. Heffler E et al. The Severe Asthma Network in Italy: Findings and Perspectives. J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1462-1468.
    4. Prescott JD et al. In Atopic Dermatitis, Looks Can Be Deceiving. Am J Manag Care 2016 (Suppl).

    Stai abbandonando il Sito

    Ti informiamo che quanto contenuto nel nuovo sito prescelto non è responsabilità di Sanofi Italia.

    Continua