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Bibliografia

HOMEPAGE

Licari A et al. Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents. Paediatr Drugs. 2020 Jun;22(3):295-310.

DUPIXENT NELL’ASMA GRAVE

Che cos’è Dupixent

Busse WW et al. Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma. Adv Ther. 2018 May;35(5):737-748.
Corren J et al. Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma. Ann Allergy Asthma Immunol. 2019 Jan;122(1):41-49.e2.
Global Initiative for Asthma. Diagnosis and Management of Difficult-to-treat and Severe Asthma in adolescent and adult patients. v2.0 April 2019, Pocket Guide.
Canonica GW. Type 2 Inflammation and the Evolving Profile of Uncontrolled Persistent Asthma. EMJ. 2018;3[4]:24-33.
Dupixent®. Riassunto delle Caratteristiche del Prodotto.

Meccanismo d’azione

Pelaia C et al. Dupilumab for the treatment of asthma. Expert Opin Biol Ther. 2017 Dec;17(12):1565-1572.
Corren J et al. Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526.
Robinson D et al. Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017 Feb;47(2):161-175.
Vatrella A et al. Dupilumab: a novel treatment for asthma. J Asthma Allergy. 2014 Sep 4;7:123-30.
Dupixent®. Riassunto delle Caratteristiche del Prodotto.
Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.

Efficacia, Sicurezza e Posologia

Corren J et al. Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526.
Bourdin A et al. Allergy. 2020 Oct 3. doi: 10.1111/all.14611. Epub ahead of print.
Bourdin A et al. Allergy. 2020 Oct 3. doi: 10.1111/all.14611. Epub ahead of print. Supplementary.
Rabe KF et al. N Engl J Med. 2018;378(26):2475-2485.
Rabe KF et al. N Engl J Med. 2018;378(26):2475-2485. Supplementary.
Dupixent®. Riassunto delle Caratteristiche del Prodotto.
Corren J et al. Dupilumab improves symptoms, quality of life, and productivity in uncontrolled persistent asthma. Ann Allergy Asthma Immunol. 2019 Jan;122(1):41-49.e2.
Doran E et al. Interleukin-13 in Asthma and Other Eosinophilic Disorders. Front Med (Lausanne). 2017 Sep 19;4:139.

Piano Terapeutico e RCP

Piano terapeutico AIFA per la prescrizione SSN di Dupixent® nell’asma grave con infiammazione di Tipo 2.
Dupixent®. Riassunto delle Caratteristiche del Prodotto.

DUPIXENT NELLA POLIPOSI NASALE GRAVE

Che cos’è Dupixent

Busse WW et al. Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma. Adv Ther. 2018 May;35(5):737-748.
EMA - Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 16-19 September 2019. https://www.ema.europa.eu/en/news/meeting-highlights-committee-medicinal-products-human-use-chmp-16-19-september-2019. (Ultimo accesso: 23/11/2020).
Dupixent®. Riassunto delle Caratteristiche del Prodotto.
Bachert C et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet 2019 Nov 2; 394(10209):1638-1650.

Meccanismo d’azione

Corren J et al. Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526.
Chaaban MR et al. Epidemiology and differential diagnosis of nasal polyps. Am J Rhinol Allergy. Nov-Dec 2013;27(6):473-8.
Gandhi NA et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov 2016;15(1):35-50.
Schleimer RP. Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. Annu Rev Pathol. 2017;12:331-357.
Vatrella A et al. Dupilumab: a novel treatment for asthma. J Asthma Allergy. 2014 Sep 4;7:123-30.
Dupixent®. Riassunto delle Caratteristiche del Prodotto.

Efficacia, Sicurezza e Posologia

Dupixent®. Riassunto delle Caratteristiche del Prodotto.
Bachert C et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet 2019 Nov 2; 394(10209):1638-1650.
Bachert C, et al. Lancet 2019 Nov 2; 394(10209):1638-1650. Supplementary.
Kang XR et al. A prediction modeling based on SNOT-22 score for endoscopic nasal septoplasty: a retrospective study. PeerJ 2020 Sep 11;8:e9890.
Dupixent®. Foglio illustrativo.

Piano Terapeutico e RCP

Piano terapeutico AIFA per la prescrizione SSN di Dupixent® (dupilumab) nella CRSwNP.

* Questa sezione del sito contiene materiali informativi relativi a Dupixent:

Si sottolinea che Dupixent è indicato in Poliposi Nasale Grave, Asma Grave, Dermatite Atopica da moderata a grave e la sua prescrizione è limitata alle seguenti classi di specialisti:

rinosinusite

RINOSINUSITE CRONICA
CON POLIPOSI NASALE
(CRSWNP)

Otorinolaringoiatra, Allergologo, Immunologo

asma

ASMA

Pneumologo, Allergologo, Immunologo

dermatite

DERMATITE ATOPICA

Dermatologo, Pediatra, Pneumologo, Allergologo, Immunologo (pazienti adulti e adolescenti da 300mg) - Dermatologo, Pediatra, Pneumologo, Allergologo, Immunologo (pazienti adolescenti da 200mg)

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